NCAA2 Games/Schedule (2021-2022)
| DePaul Games/Schedule | |||||||
| Regular Season | |||||||
| Nov. 4, 2021 | Day 17 | Montevallo - DePaul | 63-67  | ||||
NCAA1 Games/Schedule (2021-2022)
| DePaul Games/Schedule | |||||||
| Regular Season | |||||||
| Nov. 10, 2021 | Day 2 | Coppin St. - DePaul | 72-97 | ||||
| Nov. 13, 2021 | Day 5 | CMU - DePaul | 66-99 | ||||
| Nov. 18, 2021 | Day 10 | Rutgers - DePaul | 70-73 | ||||
| Nov. 20, 2021 | Day 12 | W.Illinois - DePaul | 80-84 | ||||
| Nov. 26, 2021 | Day 18 | NKU - DePaul | 68-77 | ||||
| Nov. 28, 2021 | Day 20 | EMU - DePaul | 63-101 | ||||
| Dec. 4, 2021 | Day 26 | Loyola, IL - DePaul | 68-64  | ||||
| Dec. 7, 2021 | Day 29 | Duquesne - DePaul | 67-87 | ||||
| Dec. 10, 2021 | Day 32 | DePaul - Louisville | 62-55 | ||||
| Dec. 14, 2021 | Day 36 | DePaul - UIC | 72-66 | ||||
| Dec. 29, 2021 | Day 47 | DePaul - Butler | 59-63 | ||||
| Jan. 1, 2022 | Day 50 | Providence (10) - DePaul | 70-53 | ||||
| Jan. 5, 2022 | Day 54 | DePaul - St.John's | 84-89 | ||||
| Jan. 8, 2022 | Day 57 | Villanova (8) - DePaul | 79-64 | ||||
| Jan. 11, 2022 | Day 60 | DePaul - Marquette | 76-87 | ||||
| Jan. 13, 2022 | Day 62 | Seton Hall - DePaul | 92-96 | ||||
| Jan. 19, 2022 | Day 68 | Xavier - DePaul | 68-67 | ||||
| Jan. 22, 2022 | Day 71 | DePaul - Creighton | 47-60 | ||||
| Jan. 25, 2022 | Day 74 | DePaul - Villanova (8) | 43-67 | ||||
| Jan. 29, 2022 | Day 78 | UConn (17) - DePaul | 57-50 | ||||
| Feb. 5, 2022 | Day 85 | DePaul - Xavier | 69-65 | ||||
| Feb. 9, 2022 | Day 89 | Georgetown - DePaul | 74-82 | ||||
| Feb. 12, 2022 | Day 92 | DePaul - Providence (10) | 73-76 | ||||
| Feb. 15, 2022 | Day 95 | Butler - DePaul | 73-71 | ||||
| Feb. 17, 2022 | Day 97 | Creighton - DePaul | 71-59 | ||||
| Feb. 19, 2022 | Day 99 | DePaul - Seton Hall | 64-66 | ||||
| Feb. 24, 2022 | Day 104 | DePaul - Georgetown | 68-65 | ||||
| Feb. 27, 2022 | Day 107 | St.John's - DePaul | 94-99 | ||||
| Mar. 2, 2022 | Day 110 | Marquette - DePaul | 80-91 | ||||
| Mar. 5, 2022 | Day 113 | DePaul - UConn (17) | 68-75 | ||||
| Mar. 9, 2022 | Day 117 | DePaul - St.John's | 73-92 | ||||
